Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.

@article{Smeal1992OncoproteinmediatedSC,
  title={Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.},
  author={Tod Smeal and Bernard Bin{\'e}truy and Dan Mercola and Amita Grover-Bardwick and Gisela Heidecker and Ulf R{\"u}diger Rapp and Michael Karin},
  journal={Molecular and cellular biology},
  year={1992},
  volume={12 8},
  pages={3507-13}
}
In resting cells, c-Jun is phosphorylated on five sites. Three of these sites reside next to its DNA binding domain and negatively regulate DNA binding. In response to expression of oncogenic Ha-Ras, phosphorylation of these sites decreases, while phosphorylation of two other sites within c-Jun's activation domain is greatly enhanced. Phosphorylation of these residues, serines 63 and 73, stimulates the transactivation function of c-Jun and is required for oncogenic cooperation with Ha-Ras. We… CONTINUE READING