Onconase and amphinase, the antitumor ribonucleases from Rana pipiens oocytes.

@article{Ardelt2008OnconaseAA,
  title={Onconase and amphinase, the antitumor ribonucleases from Rana pipiens oocytes.},
  author={Wojciech Ardelt and Kuslima Shogen and Zbigniew Darzynkiewicz},
  journal={Current pharmaceutical biotechnology},
  year={2008},
  volume={9 3},
  pages={215-25}
}
Rana pipiens oocytes contain two homologues of pancreatic ribonuclease A that are cytostatic and cytotoxic to human cancer cells. Extensively studied Onconase is in advanced Phase IIIb clinical trials against malignant mesothelioma, while Amphinase is a novel enzyme in pre-clinical development. Onconase is the smallest (104 amino acid residues) member of the ribonuclease A superfamily while Amphinase (114 residues) is the largest among amphibian ribonucleases. Both enzymes share the… CONTINUE READING