Onconase, a cytotoxic ribonuclease, in combination with standard of care agents in non-small cell lung tumorgraft models.


e13520 Background: Onconase is a cytotoxic amphibian ribonuclease of the RNAse A superfamily. It is currently being evaluated in phase I/II trials and has been shown to possess anti-tumor activity in many preclinical studies. In an effort to identify clinical indications for Onconase, non-small cell lung tumografts were treated with a combination of… (More)


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