Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells

@article{Yin2006OncomodulinIA,
  title={Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells},
  author={Yuqin Yin and Michael T. Henzl and Barbara Lorber and Toru Nakazawa and Tommy T. Thomas and Fan Jiang and Robert Langer and Larry I. Benowitz},
  journal={Nature Neuroscience},
  year={2006},
  volume={9},
  pages={843-852}
}
The optic nerve, like most mature CNS pathways, does not regenerate after injury. [] Key Result Depletion of oncomodulin from macrophage-conditioned media (MCM) eliminates the axon-promoting activity of MCM. The effects of oncomodulin involve downstream signaling via Ca2+/calmodulin kinase and gene transcription. In vivo, oncomodulin released from microspheres promotes regeneration in the mature rat optic nerve. Oncomodulin also stimulates outgrowth from peripheral sensory neurons. Thus, oncomodulin is a new…
Oncomodulin derived from regeneration-associated macrophages in dorsal root ganglia after preconditioning injury promotes sensory axon regeneration in the spinal cord
TLDR
It is reported that oncomodulin (ONCM) is an effector molecule derived from regeneration-associated macrophages and NG-mediated ONCM delivery could be exploited as a therapeutic strategy for promoting sensory axon regeneration following spinal cord injury.
Long-Distance Axon Regeneration in the Mature Optic Nerve: Contributions of Oncomodulin, cAMP, and pten Gene Deletion
TLDR
It is shown that the induction of a controlled inflammatory response in the eye, when combined with elevation of intracellular cAMP and deletion of the gene encoding pten, enables RGCs to regenerate axons the full length of the optic nerve in mature mice.
Neutrophils Express Oncomodulin and Promote Optic Nerve Regeneration
TLDR
It is shown here that neutrophils, the first responders of the innate immune system, play a central role in inflammation-induced regeneration and can promote axon regeneration in the CNS.
Oncomodulin links inflammation to optic nerve regeneration
TLDR
It is shown that intraocular inflammation causes infiltrative cells of the innate immune system to secrete high levels of Ocm, and that agents that prevent Ocm from binding to its receptor suppress axon regeneration.
Artemin augments survival and axon regeneration in axotomized retinal ganglion cells
TLDR
Artemin/GFRα3, but not other GDNF family members, may be of value for optic nerve regeneration in mature mammals because of its effect on axon regeneration in RGCs both in vivo and in vitro.
Reaching the brain: Advances in optic nerve regeneration
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TLDR
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TLDR
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TLDR
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TLDR
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