OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma

@article{Medina2010OncomiRAI,
  title={OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma},
  author={P. Medina and M. Nolde and F. Slack},
  journal={Nature},
  year={2010},
  volume={467},
  pages={86-90}
}
MicroRNAs (miRNAs) belong to a recently discovered class of small RNA molecules that regulate gene expression at the post-transcriptional level. [...] Key Method To explore the role of miR-21 in cancer in vivo, we used Cre and Tet-off technologies to generate mice conditionally expressing miR-21. Here we show that overexpression of miR-21 leads to a pre-B malignant lymphoid-like phenotype, demonstrating that mir-21 is a genuine oncogene. When miR-21 was inactivated, the tumours regressed completely in a few…Expand
MicroRNAs: master regulators of drug resistance, stemness, and metastasis
TLDR
The role of miRNAs in driving drug resistance and metastasis which are associated with stem cell properties of cancer cells and current delivery strategies to sensitize refractory cells and to prevent metastasis are focused on. Expand
MicroRNAs and human cancer.
TLDR
The key role of miRNA in carcinogenesis reveals a new layer in the molecular architecture of cancer, which may serve as molecular biomarkers for tumor diagnosis, prognosis of disease-specific outcomes, and prediction of therapeutic responses. Expand
MicroRNAs and human cancer.
TLDR
The key role of miRNA in carcinogenesis reveals a new layer in the molecular architecture of cancer, which may serve as molecular biomarkers for tumor diagnosis, prognosis of disease-specific outcomes, and prediction of therapeutic responses. Expand
MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells
TLDR
It is found that the expression of miR-125b protects against apoptosis induced by growth factor withdrawal, and that it blocks the differentiation of pre-B to immature B cells, and indicates that MAP3K11 might function as an important tumor suppressor neutralized by oncomiR- 125b in B-cell leukemia. Expand
Increasing sensitivity to drugs in leukemias by modulation of microRNA expression
TLDR
It is shown that by downregulating mR-21 expression with antimiRs, in K562 (CML) cells, there was a decreases in cellular viability and a decrease in cellular proliferation, which was described for the first time autophagy induction via miR- 21 downregulation and its involvement in drug sensitivity. Expand
The role of microRNA in resistance to breast cancer therapy
TLDR
The role of dysregulated miRNAs in breast cancer that are linked to resistance against chemo‐, radiation, hormone, and targeted therapies is reviewed and the role of miRN as oncogenes or tumor‐suppressor genes is briefly discussed. Expand
microRNAs, an active and versatile group in cancers
TLDR
The versatile roles of miRNAs in cancers and their potential applications for diagnosis, prognosis, and treatment as biomarkers are reviewed. Expand
Relevance of miR-21 in HIV and non-HIV-related lymphomas
TLDR
It has been shown that high levels of B cell activation were induced by miR-21 in circulating B cells and are seen in HIV-infected individual, suggesting its assistance in maintaining B cell hyperactivation, which plays a pivotal role in HIV'sinfected cells. Expand
Small molecule inhibition of microRNA-21 expression reduces cell viability and microtumor formation.
TLDR
The discovery of a new small molecule inhibitor of miR-21 is reported and its potential as an alternative approach in cancer therapy is demonstrated. Expand
MicroRNAs in cancer therapeutic response: Friend and foe.
TLDR
Recent progress in studies on miRNA function in cancer initiation, metastasis and therapeutic response, focusing on breast cancer is summarized. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 34 REFERENCES
MicroRNAs and cancer: An overview
TLDR
Although microRNAs have been discovered in humans a mere eight years ago, a host of promising potential applications in the diagnosis, prognoses and therapy of cancer are emerging at a rapid pace. Expand
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.
TLDR
It is shown that the highly malignant human brain tumor, glioblastoma, strongly over-expresses a specific miRNA, miR-21, which may contribute to the malignant phenotype by blocking expression of critical apoptosis-related genes. Expand
miR-21-mediated tumor growth
TLDR
The results suggest that miR-21 functions as an oncogene and modulates tumorigenesis through regulation of genes such as bcl-2 and thus, it may serve as a novel therapeutic target. Expand
MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
MicroRNAs (miRNAs) are a class of naturally occurring small non-coding RNAs that target protein-coding mRNAs at the post-transcriptional level. Our previous studies suggest that mir-21 functions asExpand
MicroRNA gene expression deregulation in human breast cancer.
TLDR
It is shown that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer, and the overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated mi RNAs being mir-125b, mir-145, mir -21, and mir-155. Expand
Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia.
TLDR
The results of this study offer for the first time a comprehensive and quantitative profile of miRNA expression in CLL and their healthy counterpart, suggesting that miRNAs could play a primary role in the disease itself. Expand
A microRNA expression signature of human solid tumors defines cancer gene targets
  • S. Volinia, G. Calin, +15 authors C. Croce
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2006
TLDR
The results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes. Expand
Oncomirs — microRNAs with a role in cancer
TLDR
Evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. Expand
MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells.
TLDR
The data suggested that miR-21 could promote apoptosis resistance, motility, and invasion in prostate cancer cells and these effects of mi R-21 may be partly due to its regulation of PDCD4, TPM1, and MARCKS. Expand
MicroRNA expression profiling in classic Hodgkin lymphoma.
TLDR
Analysis of miRNA expression in classic Hodgkin lymphoma and the influence of Epstein-Barr virus infection suggest that miRNAs play an important role in the biology of cHL and may be useful in developing therapies targeting miRNAAs. Expand
...
1
2
3
4
...