Oncolytic influenza A virus expressing interleukin‐15 decreases tumor growth in vivo

  title={Oncolytic influenza A virus expressing interleukin‐15 decreases tumor growth in vivo},
  author={K. Hock and J. Laengle and I. Kuznetsova and A. Egorov and B. Hegedűs and B. Dome and T. Wekerle and M. Sachet and M. Bergmann},
  • K. Hock, J. Laengle, +6 authors M. Bergmann
  • Published 2017
  • Biology, Medicine
  • Surgery
  • Background. Interleukin‐15 has become a promising molecule in the context of eliciting an effective, antitumor immune response because it is able to stimulate cells of the innate and adaptive immune system. Methods. We generated an interleukin‐15‐expressing oncolytic influenza A virus for the treatment of an established murine tumor model. Results. Our oncolytic influenza A virus produced large amounts of interleukin‐15 and induced proliferation and activation of human T cells in vitro… CONTINUE READING
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