Oncolytic immunotherapy of advanced solid tumors with a CD40L-expressing replicating adenovirus: assessment of safety and immunologic responses in patients.

@article{Pesonen2012OncolyticIO,
  title={Oncolytic immunotherapy of advanced solid tumors with a CD40L-expressing replicating adenovirus: assessment of safety and immunologic responses in patients.},
  author={Sari Pesonen and Iulia Diaconu and Lotta Kangasniemi and Tuuli Ranki and Anna Kanerva and Saila K. Pesonen and Ulrike Gerdemann and Ann M. Leen and Kalevi Kairemo and Minna Oksanen and Elina Haavisto and Sirkka-Liisa Holm and Aila Karioja-Kallio and Satu Kauppinen and Kaarina P L Partanen and Leena Laasonen and Tima Joensuu and Tuomo Alanko and Vincenzo Cerullo and Akseli Hemminki},
  journal={Cancer research},
  year={2012},
  volume={72 7},
  pages={1621-31}
}
The immunosuppressive environment of advanced tumors is a primary obstacle to the efficacy of immunostimulatory and vaccine approaches. Here, we report an approach to arm an oncolytic virus with CD40 ligand (CD40L) to stimulate beneficial immunologic responses in patients. A double-targeted chimeric adenovirus controlled by the hTERT promoter and expressing CD40L (CGTG-401) was constructed and nine patients with progressing advanced solid tumors refractory to standard therapies were treated… CONTINUE READING

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