Oncolytic herpesvirus with secretable angiostatic proteins in the treatment of human lung cancer cells.

Abstract

BACKGROUND The wild-type herpes simplex virus type 1 (HSV-1) has strong infectivity and cytolytic effect on almost all types of mammalian cells. Genetic engineering can now restrict this cytolysis to only malignant cells. G207 is an oncolytic HSV-1 vector developed based on this strategy. MATERIALS AND METHODS We used G207 as the backbone and integrated… (More)

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