Oncolytic enteroviruses

  title={Oncolytic enteroviruses},
  author={Peter M. Chumakov and Vera V. Morozova and I. V. Babkin and I. K. Baikov and S. V. Netesov and Nina V. Tikunova},
  journal={Molecular Biology},
The growing body of knowledge concerning the molecular biology of viruses and virus-cell interactions provides possibilities to use viruses as a tool in an effort to treat malignant tumors. As a rule, tumor cells are highly sensitive to viruses, which can be used in cancer therapy. At the same time, the application of viral oncolysis in cancer treatment requires that the highest possible safety be ensured for both the patient and environment. Human enteroviruses are a convenient source for… 
Oncolytic Viruses in Tumor Therapy: The Russian Perspective
Biotechnological advances in the development of therapeutic applications of OVs in Russia are discussed, with particular emphasis on the OV-mediated treatment of glioblastoma.
Oncolysis by paramyxoviruses: multiple mechanisms contribute to therapeutic efficiency
Oncolytic paramyxoviruses include some strains of Measles, Mumps, Newcastle disease, and Sendai viruses. All these viruses are well equipped for promoting highly specific and efficient malignant cell
Could Oncolytic Viruses Provide a Breakthrough in Oncology?
  • P. Chumakov
  • Medicine, Biology
    Herald of the Russian Academy of Sciences
  • 2019
To incorporate viral cancer therapy into mainstream medical practice, it is necessary to intensify basic research on viral oncolysis mechanisms, to develop new therapeutic viral strains and tests for their personalized selection, and to improve methods of the local and systemic delivery of on colytic viruses to tumor locations.
The role of immunogenic cell death in oncolytic herpes simplex virus-1 infection of cancer cells
It is showed that HSV-1716-induced cell death displays two markers of IA yet does not seem to rely solely on apoptosis to kill cells, even in cells that are competent to typical necroptosis, and this finding may prove to have great utility for producing the next generation of oncolytic viral therapeutics which can induce greater levels of proimmunogenic cell death.
The State of The Jak/Stat Pathway Affects the Sensitivity of Tumor Cells to Oncolytic Enteroviruses
A test of the sensitivity of seven colon cancer cell lines to a panel of 12 nonpathogenic human enteroviruses revealed significant differences in the ability of tumor cells to become infected and
Relationship between Cell Receptors and Tumor Cell Sensitivity to Oncolytic Enteroviruses
Differences in the expression of CXADR cell receptor did not correlate with susceptibility to infection and replication of Coxsackie B virus, but complete inactivation of CxADR gene and poliovirus receptor gene (PVR) led to loss of the sensitivity of tumor cells to viruses.
Bioselection of coxsackievirus B6 strain variants with altered tropism to human cancer cell lines
It is shown that a non-pathogenic strain of coxsackievirus B6 (LEV15) can efficiently replicate to high titers in the malignant human cell lines C33A, DU145, AsPC-1 and SK-Mel28, although it displays much lower replication efficiency in A431 and A549 cells and very limited replication ability in RD and MCF7 cells.
Low pathogenic human enteroviruses as novel anti-cancer agents against malignant glioma
The selective targeting of CVA21, CVA 21-DAFv and EV1 is based on the overexpression of the cellular receptors intercellular adhesion molecule1 (ICAM-1), decay accelerating factor (DAF) and integrin α2β1 on the surface of many cancer cells compared to normal cells.
Developing Picornaviruses for Cancer Therapy
This review focuses on the picornaviruses investigated for anticancer potential and the mechanisms that underpin this specificity.
Combinatorial Approaches for Cancer Treatment Using Oncolytic Viruses: Projecting the Perspectives through Clinical Trials Outcomes
A review of the efficacy and safety of virotherapy and the most promising combinations based on the published clinical data, rather than presenting all oncolytic virus variations, which are discussed in comprehensive literature reviews.


Replication-selective oncolytic viruses in the treatment of cancer
The use of tumor-selective viruses in conjunction with other standard therapies seems most promising, however, still several hurdles regarding clinical limitations and safety issues should be overcome before this mode of therapy can become of clinical relevance.
Viral oncolysis by herpes simplex virus and other viruses
Methods to non-invasively monitor sites of viral replication is required for preclinical and clinical studies and the design of HSV-1 viral mutants, and monitoring their replication by PET are reviewed.
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  • Biology, Medicine
    Current topics in microbiology and immunology
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This chapter provides an integrated overview of strategies to improve the efficiency of virus replication and cell killing while ensuring the specificity of these activities for tumor cells in oncolytic adenoviruses.
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This review aims to describe the transductional targeting strategies currently employed to specifically redirect viruses towards surface receptors on tumor cells.
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Three possible scenarios that could be relevant for therapy are investigated and mathematical models are presented that identify the parameters that need to be measured and modulated to evaluate and refine the existing therapy regimes.
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  • 1952
The conditions under which the sarcoma 180 is destroyed by the virus of Russian encephalitis, the tumor-virus system which the authors have studied most thoroughly, are described here.
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The novel concept of beneficial viruses was proposed which suggested that the process of co-evolution of the host organism and its associated viral flora led to a specific interaction between them that was beneficial for both.