Oncolytic adenoviruses targeted to cancer stem cells.

  title={Oncolytic adenoviruses targeted to cancer stem cells.},
  author={Joshua J Short and David T. Curiel},
  journal={Molecular cancer therapeutics},
  volume={8 8},
Cancer stem cells (CSC) represent a distinct subpopulation of cancer cells of integral importance. CSCs embody the refractory nature observed among many cancers: very competent initial tumor establishment and extremely aggressive metastatic nature. Recent discoveries indicate that CSCs embody chemo- and radioresistance and have been correlated with advanced disease and resistance to current therapies, and thus help explain the treatment resistance of many cancers. As CSCs are critical for tumor… CONTINUE READING
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Elevated circulating endothelial progenitor Molecular Cancer Therapeutics Mol Cancer Ther 2009;8(8)

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