Oncolytic adenoviral vectors which employ the survivin promoter induce glioma oncolysis via a process of beclin-dependent autophagy.

@article{Ulasov2009OncolyticAV,
  title={Oncolytic adenoviral vectors which employ the survivin promoter induce glioma oncolysis via a process of beclin-dependent autophagy.},
  author={Ilya V Ulasov and Mathew A Tyler and Zeng Bian Zhu and Yu Han and T. X. He and Maciej S. Lesniak},
  journal={International journal of oncology},
  year={2009},
  volume={34 3},
  pages={729-42}
}
Survivin has gained attention as a tumor-specific marker which is upregulated in a variety of neoplasms. Although the survivin protein is implicated in anti-apoptotic tumor pathways, little is known about the function of the survivin promoter. In this study, we constructed a conditionally replicative adenoviral vector (CRAd) that utilizes the survivin… CONTINUE READING