Oncolytic Viruses: Clinical Applications as Vectors for the Treatment of Malignant Gliomas

@article{Shah2003OncolyticVC,
  title={Oncolytic Viruses: Clinical Applications as Vectors for the Treatment of Malignant Gliomas},
  author={Amish C. Shah and Dale J. Benos and George Yancey Gillespie and James M Markert},
  journal={Journal of Neuro-Oncology},
  year={2003},
  volume={65},
  pages={203-226}
}
Gene therapy using viral vectors for the treatment of primary brain tumors has proven to be a promising novel treatment modality. Much effort in the past has been placed in utilizing replication-defective viruses to this end but they have shown many disadvantages. Much recent attention has been focused on the potential of replication-competent viruses to discriminatingly target, replicate within, and destroy tumor cells via oncolysis, leaving adjacent post-mitotic neurons unharmed. The… CONTINUE READING

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