Oncolysis by paramyxoviruses: multiple mechanisms contribute to therapeutic efficiency

@article{Matveeva2015OncolysisBP,
  title={Oncolysis by paramyxoviruses: multiple mechanisms contribute to therapeutic efficiency},
  author={Olga V. Matveeva and Zong Sheng Guo and Svetlana A. Shabalina and Peter M. Chumakov},
  journal={Molecular Therapy Oncolytics},
  year={2015},
  volume={2}
}
Oncolytic paramyxoviruses include some strains of Measles, Mumps, Newcastle disease, and Sendai viruses. All these viruses are well equipped for promoting highly specific and efficient malignant cell death, which can be direct and/or immuno-mediated. A number of proteins that serve as natural receptors for oncolytic paramyxoviruses are frequently overexpressed in malignant cells. Therefore, the preferential interaction of paramyxoviruses with malignant cells rather than with normal cells is… 
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In general, preclinical studies and phase 1–3 clinical trials yield very encouraging results and warrant continued research of oncolytic paramyxoviruses as a particularly valuable addition to the existing panel of cancer-fighting approaches.
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Prospects for Using Expression Patterns of Paramyxovirus Receptors as Biomarkers for Oncolytic Virotherapy
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The potential of fusogenic oncolytic viruses as optimal candidates to enhance immunotherapy and initiate broad antitumor responses is discussed, and growing evidence indicates that fusogenicity could be an important feature to consider in the design of optimal onColytic virus platforms for combinatorial on colytic immunotherapy.
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This is the first description of oncolysis by an NDV strain in canine mammary cancer cells, and specific molecular pathways related to NDV susceptibility in these cancer cells are demonstrated, opening the possibility to use NDV as a therapeutic-targeted option for more malignant CMCs.
Biochemical variations in cytolytic activity of ortho- and paramyxoviruses in human lung tumor cell culture
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An optimal strategy for oncolytic virus-mediated destruction of tumor cells in cancer patients requires selection of the most appropriate oncoleytic virus based on the mechanism of its cytolytic action in a particular type of tumor.
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  • P. Chumakov
  • Medicine, Biology
    Herald of the Russian Academy of Sciences
  • 2019
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To incorporate viral cancer therapy into mainstream medical practice, it is necessary to intensify basic research on viral oncolysis mechanisms, to develop new therapeutic viral strains and tests for their personalized selection, and to improve methods of the local and systemic delivery of on colytic viruses to tumor locations.
Bioselection of coxsackievirus B6 strain variants with altered tropism to human cancer cell lines
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It is shown that a non-pathogenic strain of coxsackievirus B6 (LEV15) can efficiently replicate to high titers in the malignant human cell lines C33A, DU145, AsPC-1 and SK-Mel28, although it displays much lower replication efficiency in A431 and A549 cells and very limited replication ability in RD and MCF7 cells.
Oncolytic Viruses in Tumor Therapy: The Russian Perspective
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Biotechnological advances in the development of therapeutic applications of OVs in Russia are discussed, with particular emphasis on the OV-mediated treatment of glioblastoma.
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