Oncogenic v-Abl tyrosine kinase can inhibit or stimulate growth, depending on the cell context.

@article{Renshaw1992OncogenicVT,
  title={Oncogenic v-Abl tyrosine kinase can inhibit or stimulate growth, depending on the cell context.},
  author={Mark W. Renshaw and Edward T Kipreos and Michael R Albrecht and Jianming Wang},
  journal={The EMBO journal},
  year={1992},
  volume={11 11},
  pages={
          3941-51
        }
}
The v-abl oncogene of Abelson murine leukemia virus (A-MuLV) induces two opposite phenotypes in NIH3T3 cells. In the majority of cells, v-abl causes a growth arrest at the G1 phase of the cell cycle; while in a minority of cells, v-abl abrogates the requirement for growth factors. Using temperature sensitive mutants, it can be demonstrated that v-Abl tyrosine kinase is required for growth inhibition or stimulation. The two phenotypes are not caused by mutations or differences in the expression… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-3 of 3 citations