Oncogenic transformation of murine C3H 10T1/2 cells resulting from DNA double-strand breaks induced by a restriction endonuclease.


lonising radiation has been acknowledged as an effective carcinogen for several decades but the nature of the primary lesions in the DNA of exposed cells which cause them to undergo oncogenic transformation is not known. It is generally agreed that oncogenic transformation is a multistage process (Barrett & Fletcher, 1987) at the very least requiring the… (More)
DOI: 10.1038/bjc.1989.378

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