Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy.

@article{Ding2009OncogenicTC,
  title={Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy.},
  author={Wenxing Ding and H Ni and Wentao Gao and Xiaoyun Chen and Jeong Han Kang and Donna B Stolz and Jinsong Liu and Xiao-Ming Yin},
  journal={Molecular cancer therapeutics},
  year={2009},
  volume={8 7},
  pages={2036-45}
}
The proteasome and the autophagy systems are two evolutionarily conserved mechanisms for degrading intracellular materials. They are functionally coupled and suppression of the proteasome promotes autophagy. Although suppression of the proteasome leads to cell death, suppression of autophagy can be either prodeath or prosurvival. To understand the underlining mechanism of this dichotomy and its potential clinical implications, we treated various transformed and nontransformed human cells with… CONTINUE READING
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