Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer

@article{Chung2015OncogenicRO,
  title={Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer},
  author={Soo Chung and Yoon Yang Jung and In Ae Park and Hyojin Kim and Yul Ri Chung and Ji Young Kim and Soo Young Park and Seock-Ah Im and Kang S Lee and Hyeong-Gon Moon and Dong-Young Noh and Wonshik Han and Chul Hyun Lee and Tae-Yong Kim and Han Suk Ryu},
  journal={Clinical & Experimental Metastasis},
  year={2015},
  volume={33},
  pages={179-185}
}
The aim of this study is to evaluate the biological role and clinical implications of silent mating type information regulation 2 homolog 1 (SIRT1) as a novel candidate for target therapy in triple negative breast cancer (TNBC) for which there is no specific agent. 344 patients who received surgical resection for TNBC from January 2003 to December 2006 at Seoul National University Hospital were enrolled, and the role of SIRT1 protein was evaluated via immunohistochemistry on tissue samples. In… CONTINUE READING

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