Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer.

@article{Kanehira2007OncogenicRO,
  title={Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer.},
  author={Mitsugu Kanehira and Toyomasa Katagiri and Arata Shimo and Ryo Takata and Taro Shuin and Tsuneharu Miki and Tomoaki Fujioka and Yusuke Nakamura},
  journal={Cancer research},
  year={2007},
  volume={67 7},
  pages={3276-85}
}
To disclose the molecular mechanism of bladder cancer, the second most common genitourinary tumor, we had previously done genome-wide expression profile analysis of 26 bladder cancers by means of cDNA microarray representing 27,648 genes. Among genes that were significantly up-regulated in the majority of bladder cancers, we here report identification of M-phase phosphoprotein 1 (MPHOSPH1) as a candidate molecule for drug development for bladder cancer. Northern blot analyses using mRNAs of… CONTINUE READING
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