Oncogenic protein tyrosine kinases
@article{Santoro2004OncogenicPT, title={Oncogenic protein tyrosine kinases}, author={Massimo Santoro and Francesca Carlomagno and Rosa Marina Melillo and Alfredo Fusco}, journal={Cellular and Molecular Life Sciences CMLS}, year={2004}, volume={61}, pages={2954-2964} }
Abstract.RET is the receptor for glial-derived neurotrophic factor growth factors. It is a paradigm of a single gene that causes different types of human cancer when targeted by different genetic alterations. Like other receptor tyrosine kinases, once activated, RET recruits a variety of signaling molecules that mediate biological responses. Here we review data on the signaling pathways that lead to RET-mediated cell transformation and recent evidence that manipulation of RET holds promise for…
7 Citations
The Emerging Landscapes of Long Noncoding RNA in Thyroid Carcinoma: Biological Functions and Clinical Significance
- Biology, MedicineFrontiers in Oncology
- 2021
The abnormal expression of lncRNA in TC and the fundamental characteristics in TC tumorigenesis and development are summarized and the potential prognostic and therapeutic significance of lNCRNAs in TC is introduced.
Molecular determination of benign and malignant thyroid tumors
- Biology, MedicineExpert review of endocrinology & metabolism
- 2006
These findings suggest a scenario in which the fate of a thyroid tumor is determined by the specific genetic defect at the beginning, and the identification of molecular fingerprints of thyroid tumors opens novel avenues for an improved therapeutic approach.
The glycerophosphoinositols: cellular metabolism and biological functions
- BiologyCellular and Molecular Life Sciences
- 2009
It is found that the glycerophosphoinositols enhance cytokine-dependent chemotaxis in T-lymphocytes induced by SDF-1α-receptor activation, indicating roles for these compounds as modulators of T-cell signalling and T- cell responses.
[Indication and performance of endocrine surgery. The significance of molecular genetic examination].
- MedicineDer Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
- 2009
The current possibilities for molecular genetic determination of disease-specific mutations (germline and tumor DNA) and their effect on surgical procedure are discussed.
A Series of RET Fusion Spitz Neoplasms With Plaque-Like Silhouette and Dyscohesive Nesting of Epithelioid Melanocytes.
- MedicineThe American Journal of dermatopathology
- 2021
5 cases of RET fusion Spitz neoplasms are identified and characteristics features which can help with recognition of the RET subgroup of Spitz are described which include plaque-like silhouette and monotonous epithelioid cytology with expansile and dyscohesive nesting.
RET Gly691Ser mutation is associated with primary vesicoureteral reflux in the French‐Canadian population from Quebec
- BiologyHuman mutation
- 2008
This study demonstrates that the Ret Gly691Ser mutation is associated with pVUR and may be one of the genetic causes of this condition in the French‐Canadian population in Quebec.
Array CGH demonstrates characteristic aberration signatures in human papillary thyroid carcinomas governed by RET/PTC
- MedicineOncogene
- 2008
The array CGH data presented serve as a starting point for further studies on gene expression and function of genes identified in this study and should be considered as a basis for future studies on RET/PTC-positive and-negative tumours.
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