Oncogenic protein tyrosine kinases

@article{Saglio2004OncogenicPT,
  title={Oncogenic protein tyrosine kinases},
  author={G. Saglio and D. Cilloni},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2004},
  volume={61},
  pages={2897-2911}
}
  • G. Saglio, D. Cilloni
  • Published 2004
  • Biology
  • Cellular and Molecular Life Sciences CMLS
  • Abstract.Since it was first recognized, chronic myeloid leukemia (CML) has always represented a unique model to understand the molecular mechanisms underlying the onset and progression of a leukemic process. CML was the first recognized form of cancer to have a strong association with a recurrent chromosomal abnormality, the t(9;22) translocation, which generates the so-called Philadelphia (Ph)-chromosome. Twenty years later, this abnormality was shown to cover a specific molecular defect, a… CONTINUE READING
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