Oncogenic potential of retinoic acid receptor-gamma in hepatocellular carcinoma.

@article{Yan2010OncogenicPO,
  title={Oncogenic potential of retinoic acid receptor-gamma in hepatocellular carcinoma.},
  author={Ting-dong Yan and Hua Wu and Hai-ping Zhang and Na Lu and Ping Ye and Feng-hai Yu and Hu Zhou and Wen-gang Li and Xihua Cao and Yu-Ling Lin and Junxian He and Weiwei Gao and Yi Dan Zhao and Lei Xie and Jie-bo Chen and Xiaokun Zhang and Jin-zhang Zeng},
  journal={Cancer research},
  year={2010},
  volume={70 6},
  pages={
          2285-95
        }
}
Retinoic acid receptors (RAR; alpha, beta, and gamma), members of the nuclear receptor superfamily, mediate the pleiotropic effects of the vitamin A metabolite retinoic acid (RA) and derivatives (retinoids) in normal and cancer cells. Abnormal expression and function of RARs are often involved in the growth and development of cancer. However, the underlying molecular mechanisms remain largely elusive. Here, we report that levels of RARgamma were significantly elevated in tumor tissues from a… CONTINUE READING
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