Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1 ( ubiquitin y signal transduction y oncogenes y mastocytosis )

@inproceedings{Piao1996OncogenicMI,
  title={Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1 ( ubiquitin y signal transduction y oncogenes y mastocytosis )},
  author={Xianhua Piao and R Steven Paulson and Peter L. J. van der Geer and Alan Bernstein},
  year={1996}
}
Activating mutations in the Kit receptor tyrosine kinase have been identified in both rodent and human mast cell leukemia. One activating Kit mutation substitutes a valine for aspartic acid at codon 816 (D816V) and is frequently observed in human mastocytosis. Mutation at the equivalent position in the murine c-kit gene, involving a substitution of tyrosine… CONTINUE READING