Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells.

@article{Chintharlapalli2009OncogenicMI,
  title={Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells.},
  author={Sudhakar R Chintharlapalli and Sabitha Papineni and Maen Abdelrahim and Ala A Abudayyeh and Indira Jutooru and Gayathri Chadalapaka and Fei Wu and Susanne U. Mertens-Talcott and Kathryn E Vanderlaag and Sung Dae Cho and Roger Smith and Stephen Safe},
  journal={International journal of cancer},
  year={2009},
  volume={125 8},
  pages={1965-74}
}
Methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate (CDODA-Me) is a synthetic derivative of glycyrrhetinic acid, a triterpenoid phytochemical found in licorice extracts. CDODA-Me inhibited growth of RKO and SW480 colon cancer cells and this was accompanied by decreased expression of Sp1, Sp3 and Sp4 protein and mRNA and several Sp-dependent genes including survivin, vascular endothelial growth factor (VEGF), and VEGF receptor 1 (VEGFR1 or Flt-1). CDODA-Me also induced apoptosis, arrested… CONTINUE READING