Oncogenic miR-20a and miR-106a enhance the invasiveness of human glioma stem cells by directly targeting TIMP-2

@article{Wang2015OncogenicMA,
  title={Oncogenic miR-20a and miR-106a enhance the invasiveness of human glioma stem cells by directly targeting TIMP-2},
  author={Zili Wang and Bin Wang and Yan Shi and Chuanliang Xu and Hua liang Xiao and Lei Ma and Sherry Li Xu and L Yang and Qiao Ling Wang and Wen Qiang Dang and Wenbo Cui and Shih Chen Yu and Yu Feng Ping and Yu Hong Cui and Hank F Kung and Chen’ao Qian and Xin Zhang and Xiu Wu Bian},
  journal={Oncogene},
  year={2015},
  volume={34},
  pages={1407-1419}
}
  • Zili Wang, Bin Wang, +15 authors Xiu Wu Bian
  • Published in Oncogene 2015
  • Biology, Medicine
  • Emerging evidence has shown that cancer stem cells (CSCs) are the cellular determinants to promote cancer invasion and metastasis. However, the mechanism underlying CSC invasion remains unknown. MicroRNAs are evolutionally conserved small noncoding RNAs that are critical for the regulation of gene expression, and their expressions are often dysregulated in cancers. In the present study, we demonstrated that two functionally related microRNAs, miR-20a and -106a (miR-20a/106a), were capable of… CONTINUE READING

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