Oncogenic kinase NPM/ALK induces expression of HIF1α mRNA

  title={Oncogenic kinase NPM/ALK induces expression of HIF1α mRNA},
  author={Michal Marzec and X Liu and W R Wong and Y Yang and Theresa L. Pasha and Kanchan Kantekure and Ping Zhang and Anders Woetmann and Mangeng Cheng and N Joey Odum and Mariusz A Wasik},
The mechanisms of malignant cell transformation mediated by the oncogenic anaplastic lymphoma kinase (ALK) tyrosine kinase remain only partially understood. In this study, we report that T-cell lymphoma (TCL) cells carrying the nucleophosmin (NPM)/ALK fusion protein (ALK+ TCL) strongly express hypoxia-induced factor 1α (HIF1α) mRNA, even under normoxic conditions, and markedly upregulate HIF1α protein expression under hypoxia. HIF1α expression is strictly dependent on the expression and… CONTINUE READING