Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities.

@article{Qian2007OncogenicIB,
  title={Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities.},
  author={Xiaolan Qian and Guorong Li and Holly K Asmussen and Laura Asnaghi and William C. Vass and Richard Braverman and Kenneth M Yamada and Nicholas C. Popescu and Alex G. Papageorge and Douglas R Lowy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 21},
  pages={9012-7}
}
The three deleted in liver cancer genes (DLC1-3) encode Rho-GTPase-activating proteins (RhoGAPs) whose expression is frequently down-regulated or silenced in a variety of human malignancies. The RhoGAP activity is required for full DLC-dependent tumor suppressor activity. Here we report that DLC1 and DLC3 bind to human tensin1 and its chicken homolog. The binding has been mapped to the tensin Src homology 2 (SH2) and phosphotyrosine binding (PTB) domains at the C terminus of tensin proteins… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 87 extracted citations

Similar Papers

Loading similar papers…