Oncogenic drivers in 11q13 associated with prognosis and response to therapy in advanced oropharyngeal carcinomas.

@article{BarrosFilho2018OncogenicDI,
  title={Oncogenic drivers in 11q13 associated with prognosis and response to therapy in advanced oropharyngeal carcinomas.},
  author={Mateus Camargo Barros-Filho and L. A. Reis-Rosa and Marcia Hatakeyama and Fabio Albuquerque Marchi and Thiago Celestino Chulam and Cristovam Scapulatempo-Neto and Ulisses Ribaldo Nicolau and AL Carvalho and Cl{\'o}vis Ant{\^o}nio Lopes Pinto and Sandra Aparecida Drigo and Luis Paulo Kowalski and S{\'i}lvia Regina Rogatto},
  journal={Oral oncology},
  year={2018},
  volume={83},
  pages={
          81-90
        }
}
Distinctive Expression and Amplification of Genes at 11q13 in Relation to HPV Status with Impact on Survival in Head and Neck Cancer Patients
TLDR
Taken together, the distinctive expression and amplification of these genes could cooperatively contribute to the differences in prognosis and clinical outcome between HPV-positive and HPV-negative tumors.
Identifying predictors of HPV-related head and neck squamous cell carcinoma progression and survival through patient-derived models
TLDR
These findings bridge a critical gap in preclinical models for HPV+ HNSCCs and simultaneously reveal novel applications for mutational burden and E2F target dysregulation in biomarker development.
Human Papillomavirus Detected in Oropharyngeal Cancers from Chilean Subjects
TLDR
High-risk human papillomaviruses are the causal agents of an important subset of oropharyngeal cancers that has increased considerably in incidence in recent years, suggesting the necessity of additional studies to address this growing public health concern.
A novel prognostic biomarker for muscle invasive bladder urothelial carcinoma based on 11 DNA methylation signature
TLDR
The methylation signature risk model based on 11 DMRs may be a reliable prognostic signature for MIBC, which provides new insights into development of individualized therapy for MI BC.
Human papillomavirus prevalence in oral and oropharyngeal squamous cell carcinoma in South America: A systematic review and meta-analysis
TLDR
The overall prevalence of HPV was found in 24.31% of oral and oropharyngeal squamous cell carcinomas in South American patients, which is higher than the prevalence in other parts of the world.
SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling
TLDR
Results suggest that SHANK2 is an evolutionarily conserved Hippo pathway regulator, commonly amplified in human cancer and potently promotes cancer.
CPT1A-mediated fatty acid oxidation promotes cell proliferation via nucleoside metabolism in nasopharyngeal carcinoma
TLDR
It is found that CPT1A is a determining factor for the abnormal activation of FAO in nasopharyngeal carcinoma (NPC) cells, which supplements additional experimental evidence for developing a therapeutic mechanism based on manipulating lipid metabolism.
Liprins in oncogenic signaling and cancer cell adhesion
TLDR
The available data indicate that liprins may be potential biomarkers for cancer progression and may have therapeutic importance.
...
...

References

SHOWING 1-10 OF 59 REFERENCES
Chromosomal imbalances exclusively detected in invasive front area are associated with poor outcome in laryngeal carcinomas from different anatomical sites
TLDR
Regions that could be targeted in the search for molecular markers in LSCC are revealed and cyclin D1 may be useful as a prognostic marker in supraglottic tumors.
Genomic Profiling of Human Penile Carcinoma Predicts Worse Prognosis and Survival
TLDR
Recurrent copy-number alterations and its potential prognostic value in penile carcinomas are described and a specific genomic profile according to HPV infection is shown, supporting the hypothesis that penile tumors present distinct etiologies according to virus status.
Genetic Signatures of HPV-related and Unrelated Oropharyngeal Carcinoma and Their Prognostic Implications
TLDR
Patients with human papillomavirus-containing oropharyngeal squamous cell carcinomas (OSCC) have a better prognosis than patients with HPV-negative OSCC, and distinct chromosomal alterations have prognostic significance.
11q13 amplification status and human papillomavirus in relation to p16 expression defines two distinct etiologies of head and neck tumours
TLDR
It is hypothesised that HPV infection may represent an early event in the HNSCC carcinogenic process, thus suggesting a distinct molecular pathway, and lack the genetic alterations which are common in other tumours.
Genomic Profiling of Advanced-Stage Oral Cancers Reveals Chromosome 11q Alterations as Markers of Poor Clinical Outcome
TLDR
This study identifies a tractable number of genomic alterations with few underlying genes that may potentially be utilized as biological markers for prognosis and treatment decisions in oral cancers.
Genomic alterations with impact on survival in esophageal squamous cell carcinoma identified by array comparative genomic hybridization
TLDR
The data suggest that gain of CPT1A may be a candidate prognostic factor for esophageal squamous cell carcinoma, andarray comparative genomic hybridization on a screening set of 35 tumor samples from ESCC patients confirmed that C PT1A gain provided prognostic information in ESCC.
Integrative and Comparative Genomic Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas
TLDR
The mutational makeup of HPV-positive and HPV-negative HNSCC differs significantly, including targetable genes, includingtargetable genomic alterations in FGFR1, DDR2, EGFR, FGFR2/3, EPHA2, and PIK3CA.
Chromosome 11q13 amplification in head and neck squamous cell carcinoma. Association with poor prognosis.
TLDR
Amplification of chromosome 11q13 loci may be an important biologic marker indicating poor prognosis, independent of clinical stage in head and neck squamous cell carcinoma, and it should be assessed in prospective trials to determine its utility for stratifying treatment and determining prognosis.
Is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality?
TLDR
Patients with HPV induced p16 positive OPSCC show a significantly better prognosis, which is reported to be caused by increased radiosensitivity, and the improved prognosis of p16positive OPSCC is found after RT as well as after surgery.
Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma
TLDR
Important criteria required to predict clinically active HPV infection are highlighted, new biological pathways implicated in HPV tumorigenesis are identified and the understanding of HPV‐HNSCC physiopathology is increased to develop new targets for therapy.
...
...