Oncogenic dependency on β-catenin in liver cancer cell lines correlates with pathway activation

@inproceedings{Ding2017OncogenicDO,
  title={Oncogenic dependency on β-catenin in liver cancer cell lines correlates with pathway activation},
  author={Zhihu Ding and Chaomei Shi and Lan Jiang and Tatiana Tolstykh and Hui Ling Cao and Dinesh S. Bangari and Susan L. Ryan and Mikhail N. Levit and Taiguang Jin and Karl Mamaat and Qunyan Yu and Hui Qu and Joern Hopke and May Cindhuchao and Dietmar Hoffmann and Fangxian Sun and Mike W. Helms and Kerstin Jahn-Hofmann and Sabine Scheidler and Liang Schweizer and Douglas D. Fang and Jack Pollard and Christopher Winter and Dmitri Wiederschain},
  booktitle={Oncotarget},
  year={2017}
}
Hepatocellular carcinoma (HCC) represents a serious public health challenge with few therapeutic options available to cancer patients.Wnt/β-catenin pathway is thought to play a significant role in HCC pathogenesis. In this study, we confirmed high frequency of CTNNB1 (β-catenin) mutations in two independent cohorts of HCC patients and demonstrated significant upregulation of β-catenin protein in the overwhelming majority of HCC patient samples, patient-derived xenografts (PDX) and established… CONTINUE READING
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