Oncogenic cooperation between H-Twist and N-Myc overrides failsafe programs in cancer cells.

@article{ValsesiaWittmann2004OncogenicCB,
  title={Oncogenic cooperation between H-Twist and N-Myc overrides failsafe programs in cancer cells.},
  author={Sandrine Valsesia-Wittmann and Maud Magdeleine and S{\'e}bastien Dupasquier and Elisabeth Garin and Anne-Catherine Jallas and Valerie Combaret and Alexander Krause and Philippe Leissner and Alain Puisieux},
  journal={Cancer cell},
  year={2004},
  volume={6 6},
  pages={625-30}
}
N-Myc oncogene amplification is a frequent event in neuroblastoma and is strongly correlated with advanced disease stage and treatment failure. Similarly to c-Myc oncogenic activation, N-Myc deregulation promotes both cell proliferation and p53-dependent apoptosis by sensitizing cells to a variety of insults. Intriguingly, p53 mutations are uncommon in neuroblastomas, strongly suggesting that an alternative cooperating event circumvents this safeguard against oncogene-driven neoplasia. By… CONTINUE READING

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