Oncogenic conversion by regulatory changes in transcription factors

@article{Lewin1991OncogenicCB,
  title={Oncogenic conversion by regulatory changes in transcription factors},
  author={Benjamin Lewin},
  journal={Cell},
  year={1991},
  volume={64},
  pages={303-312}
}
  • B. Lewin
  • Published 25 January 1991
  • Biology
  • Cell
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The hypothesis that v-rel encodes a protein which can act either in the nucleus or in the cytoplasm to transform spleen cells is supported.
Oncogenic transformation by vrel requires an amino-terminal activation domain
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The results show that the oncogenicity of Rel proteins requires activation region I and suggest that the biological function of rel and dorsal proteins depends on transcription activation by this region.
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The c-myb protooncogene encodes a sequence-specific DNA-binding protein (c-Myb) that induces transcriptional activation or repression, and three functional domains are identified that are responsible for DNA binding, transcriptionalactivation, and negative regulation, respectively.
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