Oncogenic conversion by regulatory changes in transcription factors

  title={Oncogenic conversion by regulatory changes in transcription factors},
  author={Benjamin Lewin},
  • B. Lewin
  • Published 25 January 1991
  • Biology
  • Cell
CREM, a master-switch in the nuclear response to cAMP signaling
The study, and ultimately the understanding, of these processes will help to unravel the profound changes that cause cancer and by the same token the physiology of normal growth.
The Nuclear Response to cAMP During Spermatogenesis: The Key Role of Transcription Factor CREM
The study of the regulation of gene expression by specific signal transduction pathways will hopefully help to unravel the profound changes that cause cancer and, by the same token, the physiology of normal growth.
Oncogenic conversion of Ets affects redox regulation in-vivo and in-vitro.
It is suggested that the 'open' conformation of the vEts DNA-binding domain favours interactions with other proteins or DNA and facilitates transformation and is more accessible to protein-protein interactions and to regulatory mechanisms.
COMMENTARY Negative regulation of eukaryotic transcription
This review concentrates on the better-characterised systems and the most recent work on the role of chromatin structure in repression, followed by an analysis of the different mechanisms of negative regulation.
Molecular Evolution of the Ha-ras-1 Oncogene: Relationship between DNA Methylation, Frequency of CpG Dinucleotides and Binding to the Sp1 Transacting Factor
One of the molecular events involved in the regulation of the expression of cellular oncogenes is the interaction between transcriptional factors and target DNA sequences present in the 5′ genomic
Possible involvement of nuclear oncoproteins in regulation of DNA replication.
This work has shown that protooncogenes, c-jun and c-fos, whose products form heterodimeric transcription activator, AP-1, strongly stimulate polyomavirus DNA replication through the AP- 1 site, and revealed a new domain in v-Rel protein which can stimulate replication strongly.
The ets gene family.
Regulation of Cell Growth by Transcription Factors, IRF-1 and IRF-2
This work has reported that one of the IFN species, IFN-γ, plays a critical role in induced cell death of effector T lymphocyte3, and this work aims to clarify the role of this species in this type of infection.
Oncogenic conversion alters the transcriptional properties of ets.
  • C. Wasylyk, B. Wasylyk
  • Biology
    Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
  • 1992
The results show that vEts differs from its progenitor cEts1(p68) in its trans-activating properties, and suggest that activation of the Jun and Fos oncoprotein pathway is important for transformation by Ets.


v-rel oncoproteins in the nucleus and in the cytoplasm transform chicken spleen cells
The hypothesis that v-rel encodes a protein which can act either in the nucleus or in the cytoplasm to transform spleen cells is supported.
Oncogenic transformation by vrel requires an amino-terminal activation domain
The results show that the oncogenicity of Rel proteins requires activation region I and suggest that the biological function of rel and dorsal proteins depends on transcription activation by this region.
Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene.
The c-myb protooncogene encodes a sequence-specific DNA-binding protein (c-Myb) that induces transcriptional activation or repression, and three functional domains are identified that are responsible for DNA binding, transcriptionalactivation, and negative regulation, respectively.