Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum.

  title={Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum.},
  author={Mariateresa Mancuso and Emanuela Pasquali and Simona Leonardi and Mirella Tanori and Simonetta Rebessi and Vincenzo di Majo and Simonetta Pazzaglia and Maria Pia Toni and Maria Pimpinella and Vincenzo Covelli and Anna Saran},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 34},
The central dogma of radiation biology, that biological effects of ionizing radiation are a direct consequence of DNA damage occurring in irradiated cells, has been challenged by observations that genetic/epigenetic changes occur in unexposed "bystander cells" neighboring directly-hit cells, due to cell-to-cell communication or soluble factors released by irradiated cells. To date, the vast majority of these effects are described in cell-culture systems, while in vivo validation and assessment… CONTINUE READING
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