Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling.

@article{Young2013OncogenicAW,
  title={Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling.},
  author={Amy Young and David Lou and Frank Mccormick},
  journal={Cancer discovery},
  year={2013},
  volume={3 1},
  pages={112-23}
}
UNLABELLED H-Ras, K-Ras, and N-Ras regulate cellular growth and survival and are often activated by somatic mutation in human tumors. Although oncogenic lesions occur in a single Ras isoform within individual tumors, it is unclear whether the remaining wild-type isoforms play supporting roles in tumor growth. Here, we show that oncogenic and wild-type Ras isoforms play independent and nonredundant roles within the cell. Oncogenic Ras regulates basal effector pathway signaling, whereas wild-type… CONTINUE READING
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