Oncogenic and tumor suppressive roles of polo-like kinases in human hepatocellular carcinoma.

@article{Pellegrino2010OncogenicAT,
  title={Oncogenic and tumor suppressive roles of polo-like kinases in human hepatocellular carcinoma.},
  author={Rossella Pellegrino and Diego F Calvisi and Sara Ladu and Volker Ehemann and Tommaso Staniscia and Matthias Evert and Frank Dombrowski and Peter Schirmacher and Thomas Longerich},
  journal={Hepatology},
  year={2010},
  volume={51 3},
  pages={857-68}
}
UNLABELLED Polo-like kinase (PLK) proteins play critical roles in the control of cell cycle progression, either favoring or inhibiting cell proliferation, and in DNA damage response. Although either overexpression or down-regulation of PLK proteins occurs frequently in various cancer types, no comprehensive analysis on their function in human hepatocellular carcinoma (HCC) has been performed to date. In the present study, we define roles for PLK1, PLK2, PLK3, and PLK4 during… CONTINUE READING
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