Oncogenic alterations in papillary thyroid cancers of young patients.

  title={Oncogenic alterations in papillary thyroid cancers of young patients.},
  author={Genevi{\`e}ve Sassolas and Zakia Hafdi-Nejjari and Angelo Ferraro and Myriam Decaussin-Petrucci and Bernard Rousset and Françoise Borson-Chazot and Eleonora Borbone and Nicole Berger and Alfredo Fusco},
  journal={Thyroid : official journal of the American Thyroid Association},
  volume={22 1},
BACKGROUND Papillary thyroid carcinoma (PTC) in young people usually has an aggressive initial presentation, though a good general prognosis despite recurrences in 10%-20% of patients. A number of genetic alterations that activate the mitogen-activated protein kinase (MAPK) pathway have been found in PTC. Some of these alterations have been identified as prognostic factors of PTC in adults. The objective of the current study was to comprehensively characterize all known oncogenic alterations of… CONTINUE READING
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