Oncogenic activity of retinoic acid receptor γ is exhibited through activation of the Akt/NF-κB and Wnt/β-catenin pathways in cholangiocarcinoma.

@article{Huang2013OncogenicAO,
  title={Oncogenic activity of retinoic acid receptor γ is exhibited through activation of the Akt/NF-κB and Wnt/β-catenin pathways in cholangiocarcinoma.},
  author={G L Huang and Qi Luo and Gang Rui and Wei Zhang and Qiu-Yan Zhang and Qing-Xi Chen and Dong-yan Shen},
  journal={Molecular and cellular biology},
  year={2013},
  volume={33 17},
  pages={3416-25}
}
Aberrant expression and function of retinoic acid receptor γ (RARγ) are often involved in the progression of several cancers. However, the role of RARγ in cholangiocarcinoma (CCA), chemoresistant bile duct carcinoma with a poor prognosis, remains unclear. In the present study, we found that RARγ was frequently overexpressed in human CCA specimens. Its overexpression was associated with poor differentiation, lymph node metastasis, high serum carbohydrate antigen 19-9 level, and poor prognosis of… CONTINUE READING

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