Oncogenic activity of Cdc6 through repression of the INK4/ARF locus

  title={Oncogenic activity of Cdc6 through repression of the INK4/ARF locus},
  author={Susana Gonz{\'a}lez and Peter Klatt and Sonia Delgado and Esther Conde and Fernando L{\'o}pez-R{\'i}os and Montserrat S{\'a}nchez-C{\'e}spedes and Juan M{\'e}ndez and Francisco Antequera and Manuel Serrano},
The INK4/ARF locus encodes three tumour suppressors (p15INK4b, ARF and p16INK4a) and is among the most frequently inactivated loci in human cancer. However, little is known about the mechanisms that govern the expression of this locus. Here we have identified a putative DNA replication origin at the INK4/ARF locus that assembles a multiprotein complex containing Cdc6, Orc2 and MCMs, and that coincides with a conserved noncoding DNA element (regulatory domain RDINK4/ARF). Targeted and localized… CONTINUE READING
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