Oncogenic Mutations in B-Raf Some Losses Yield Gains

@article{Hubbard2004OncogenicMI,
  title={Oncogenic Mutations in B-Raf Some Losses Yield Gains},
  author={Stevan R Hubbard},
  journal={Cell},
  year={2004},
  volume={116},
  pages={764-766}
}
A study by Wan et al. in this issue of Cell demonstrates that the majority of oncogenic mutations in the B-Raf protein kinase result in increased catalytic activity, through disruption of the autoinhibited state of the kinase domain. Surprisingly, several mutations lead to impaired B-Raf kinase activity, yet these mutants are nevertheless capable of… CONTINUE READING