Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation

@article{Carrire2008OncogenicMS,
  title={Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation},
  author={A. Carri{\`e}re and Marie Cargnello and Louis-Andr{\'e} Julien and Huanhuan Gao and {\'E}ric Bonneil and Pierre Thibault and Philippe P Roux},
  journal={Current Biology},
  year={2008},
  volume={18},
  pages={1269-1277}
}
BACKGROUND The mammalian target of rapamycin (mTOR) is a Ser/Thr kinase that controls cell growth in response to mitogens, as well as amino acid and energy sufficiency. The scaffolding protein Raptor binds to mTOR and recruits substrates to the rapamycin-sensitive mTOR complex 1 (mTORC1). Although Raptor has been shown to be essential for mTORC1 activity, the mechanisms regulating Raptor function remain unknown. RESULTS Here, we demonstrate that Raptor becomes highly phosphorylated on RXRXXpS… CONTINUE READING

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