Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo.

@article{Miller2009OncogenicKR,
  title={Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo.},
  author={Kelly A. Miller and Nicole Yeager and Kristen Baker and Xiao-Hui Liao and Samuel Refetoff and Antonio Di Cristofano},
  journal={Cancer research},
  year={2009},
  volume={69 8},
  pages={3689-94}
}
Thyroid tumors arising from the follicular cells often harbor mutations leading to the constitutive activation of the PI3K and Ras signaling cascades. However, it is still unclear what their respective contribution to the neoplastic process is, as well as to what extent they interact. We have used mice harboring a Kras oncogenic mutation and a Pten deletion targeted to the thyroid epithelium to address in vivo these questions. Here, we show that although each of these two pathways, alone, is… CONTINUE READING

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