Oncogenic Ki-ras inhibits the expression of interferon-responsive genes through inhibition of STAT1 and STAT2 expression.

@article{Klampfer2003OncogenicKI,
  title={Oncogenic Ki-ras inhibits the expression of interferon-responsive genes through inhibition of STAT1 and STAT2 expression.},
  author={Lidija Klampfer and Jie Huang and Georgia A. Corner and John M. Mariadason and Diego Arango and Takehiko Sasazuki and Senji Shirasawa and Leonard H. Augenlicht},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 47},
  pages={46278-87}
}
Endogenous interferon gamma (IFNgamma) promotes the host response to primary tumors, and IFNgamma-insensitive tumors display increased tumorigenicity and can evade tumor surveillance mechanisms. Here we demonstrate that activating mutations of Ki-ras are sufficient to inhibit the expression of STAT1 and STAT2, transcription factors required for signaling by IFNs, providing a potential mechanism for the insensitivity of tumors to IFNs. We demonstrated that colon cancer cell lines with Ki-ras… CONTINUE READING

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