Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation

Abstract

Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells. Here, we show that oncogenic KRAS (KRAS(G12D)) also regulates tumor cell signaling via stromal cells. By combining cell-specific proteome labeling with multivariate phosphoproteomics, we analyzed heterocellular KRAS(G12D) signaling in pancreatic ductal adenocarcinoma… (More)
DOI: 10.1016/j.cell.2016.05.079

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