Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion.

@article{Atay2014OncogenicKE,
  title={Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion.},
  author={S. Ahmet Atay and Samagya Banskota and Jennifer H Crow and Geetika Sethi and Lori Rink and Niroshan Ramachandran},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 2},
  pages={
          711-6
        }
}
During tumor development, constant interplay occurs between tumor cells and surrounding stromal cells. We report evidence that gastrointestinal stromal tumor (GIST) cells invade the interstitial stroma through the release of the oncogenic protein tyrosine kinase (KIT)-containing exosomes, which triggers the phenotypic conversion of progenitor smooth muscle cells to tumor-promoting cells. These recipient cells display morphologic changes and acquire tumor-associated phenotypes, including… CONTINUE READING

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