Oncogenic Hijacking of the PIN1 Signaling Network

@inproceedings{Zannini2019OncogenicHO,
  title={Oncogenic Hijacking of the PIN1 Signaling Network},
  author={Alessandro Zannini and Alessandra Rustighi and Elena Campaner and Giannino Del Sal},
  booktitle={Front. Oncol.},
  year={2019}
}
Cellular choices are determined by developmental and environmental stimuli through integrated signal transduction pathways. These critically depend on attainment of proper activation levels that in turn rely on post-translational modifications (PTMs) of single pathway members. Among these PTMs, post-phosphorylation prolyl-isomerization mediated by PIN1 represents a unique mechanism of spatial, temporal and quantitative control of signal transduction. Indeed PIN1 was shown to be crucial for… CONTINUE READING
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