Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6.

@article{Wang2009OncogenicHI,
  title={Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6.},
  author={Xiaohong Wang and Hsu-kun Wang and J. Philip McCoy and Nilam Sanjib Banerjee and Janet S Rader and Thomas R. Broker and Craig Meyers and Louise T. Chow and Zhi-Ming Zheng},
  journal={RNA},
  year={2009},
  volume={15 4},
  pages={637-47}
}
MicroRNAs (miRNA) play pivotal roles in controlling cell proliferation and differentiation. Aberrant miRNA expression in human is becoming recognized as a new molecular mechanism of carcinogenesis. However, the causes for alterations in miRNA expression remain largely unknown. Infection with oncogenic human papillomavirus types 16 (HPV16) and 18 (HPV18) can lead to cervical and other ano-genital cancers. Here, we have demonstrated that cervical cancer tissues and cervical cancer-derived cell… CONTINUE READING