Oncogenic Drivers in Myeloproliferative Neoplasms: From JAK2 to Calreticulin Mutations.

@article{Cahu2015OncogenicDI,
  title={Oncogenic Drivers in Myeloproliferative Neoplasms: From JAK2 to Calreticulin Mutations.},
  author={Xavier Cahu and Stefan N Constantinescu},
  journal={Current hematologic malignancy reports},
  year={2015},
  volume={10 4},
  pages={335-43}
}
During the past 10 years, major progress has been accomplished with the discovery of activating mutations that are associated with the vast majority of BCR-ABL negative human myeloproliferative neoplasms (MPNs). The identification in 2005 of JAK2 V617F triggered great interest in the JAK2-STAT5/STAT3 pathway. Discovery in 2006 of mutants of thrombopoietin receptor (TPO-R/MPL) and later on of mutants in negative regulators of JAK-STAT pathway led to the notion that persistent JAK2 activation is… CONTINUE READING
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