Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas

@inproceedings{Bognar2016OncogenicCC,
  title={Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas},
  author={M K Bognar and Michelle Vincendeau and Torsten Erdmann and T Seeholzer and Montserrat Grau and Jelena R. Linnemann and Jurgen Ruland and Christina H Scheel and Peter Lenz and German Ott and Gadi Lenz and Stefanie M Hauck and Daniel Krappmann},
  booktitle={Oncogene},
  year={2016}
}
Constitutive activation of the antiapoptotic nuclear factor-κB (NF-κB) signaling pathway is a hallmark of the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphomas (DLBCL). Recurrent oncogenic mutations are found in the scaffold protein CARMA1 (CARD11) that connects B-cell receptor (BCR) signaling to the canonical NF-κB pathway. We asked how… CONTINUE READING

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