Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanoma.

@article{Khalili2012OncogenicBP,
  title={Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanoma.},
  author={Jahan S. Khalili and Shujuan Liu and Tania G. Rodr{\'i}guez-Cruz and Mayra Whittington and Seth Wardell and Chengwen Liu and Minying Zhang and Zachary A Cooper and Dennie Tompers Frederick and Yufeng Li and Min Zhang and Richard W. Joseph and Chantale Bernatchez and Suhendan Ekmekcioglu and Elizabeth Ann Grimm and Laszlo G. Radvanyi and R Eric Davis and Michael A. Davies and Jennifer A Wargo and Patrick Hwu and Gregory Liz{\'e}e},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 19},
  pages={5329-40}
}
PURPOSE In this study, we assessed the specific role of BRAF(V600E) signaling in modulating the expression of immune regulatory genes in melanoma, in addition to analyzing downstream induction of immune suppression by primary human melanoma tumor-associated fibroblasts (TAF). EXPERIMENTAL DESIGN Primary human melanocytes and melanoma cell lines were transduced to express WT or V600E forms of BRAF, followed by gene expression analysis. The BRAF(V600E) inhibitor vemurafenib was used to confirm… CONTINUE READING

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