Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains.

@article{Reynoird2010OncogenesisBS,
  title={Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains.},
  author={Nicolas Reynoird and Brian E Schwartz and Manuela Delvecchio and Karin Sadoul and David Meyers and Chandrani Mukherjee and C{\'e}cile Caron and Hiroshi Kimura and Sophie Rousseaux and Philip A Cole and Daniel Panne and Christopher A French and Saadi Khochbin},
  journal={The EMBO journal},
  year={2010},
  volume={29 17},
  pages={2943-52}
}
In a subset of poorly differentiated and highly aggressive carcinoma, a chromosomal translocation, t(15;19)(q13;p13), results in an in-frame fusion of the double bromodomain protein, BRD4, with a testis-specific protein of unknown function, NUT (nuclear protein in testis). In this study, we show that, after binding to acetylated chromatin through BRD4 bromodomains, the NUT moiety of the fusion protein strongly interacts with and recruits p300, stimulates its catalytic activity, initiating… CONTINUE READING