Oncogenesis: An "Off-Target" Effect of Radiofrequency Ablation.

@article{Rozenblum2015OncogenesisA,
  title={Oncogenesis: An "Off-Target" Effect of Radiofrequency Ablation.},
  author={Nir Rozenblum and Evelyne Zeira and Viviana Scaiewicz and Baruch E. Bulvik and Svetlana Gourevitch and Hagit Yotvat and Eithan Galun and Shraga Nahum Goldberg},
  journal={Radiology},
  year={2015},
  volume={276 2},
  pages={
          426-32
        }
}
PURPOSE To compare hepatocellular carcinoma (HCC) development after radiofrequency (RF) ablation, partial surgical hepatectomy, and a sham operation and to inhibit HCC recurrence after RF ablation in a mouse model of spontaneously forming HCC in the setting of chronic inflammation (ie, the MDR2 knockout model). MATERIALS AND METHODS Animal experiments were performed according to an approved animal care committee protocol. The authors compared the survival of MDR2 knockout mice (an… Expand
Targeting STAT3 to Suppress Systemic Pro-Oncogenic Effects from Hepatic Radiofrequency Ablation.
TLDR
Gene expression analysis identified multiple pathways upregulated in the periablational rim after hepatic RFA, of which STAT3 was active in four of seven activated pathways associated with pro-oncogenic genes at network analysis. Expand
CTLA-4 Blockade Suppresses Progression of Residual Tumors and Improves Survival After Insufficient Radiofrequency Ablation in a Subcutaneous Murine Hepatoma Model
TLDR
It is demonstrated that CTLA-4 blockade injection could suppress the growth of residual tumors and improve survival after insufficient RFA in a subcutaneous murine HCC model. Expand
Irreversible Electroporation versus Radiofrequency Ablation: A Comparison of Local and Systemic Effects in a Small-Animal Model.
TLDR
Persistent patency of vasculature within the coagulated zone from IRE increases the area and accumulation of infiltrative cells that is associated with a higher serum IL-6 level than RF ablation, which induces more robust systemic effects, including both tumorigenic and immunogenic effects. Expand
Radiofrequency ablation (RFA)-induced systemic tumor growth can be reduced by suppression of resultant heat shock proteins
  • Muneeb Ahmed, G. Kumar, +4 authors S. Goldberg
  • Materials Science, Medicine
  • International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
  • 2018
TLDR
Modulation of RF heating parameters alone or in combination with adjuvant HSP inhibition can reduce unwanted, off-target systemic tumorigenic effects. Expand
Hepatic Ablation Promotes Colon Cancer Metastases in an Immunocompetent Murine Model.
TLDR
The data suggest that the method of energy delivery promotes colon cancer metastasis at the injury site, and MV and RF energy result in greater metastatic volume than cautery. Expand
Thermal Ablation Induces Transitory Metastatic Growth by Means of the STAT3/c-Met Molecular Pathway in an Intrahepatic Colorectal Cancer Mouse Model.
TLDR
Radiofrequency ablation of normal liver promotes intrahepatic metastatic implantation and increased growth over a short-lived temporal window in animal models and can be potentially neutralized with specific inhibition of pathways including hepatocyte growth factor/tyrosine-protein kinase Met and signal transducer and activator of transcription 3. Expand
Hepatic Thermal Ablation: Effect of Device and Heating Parameters on Local Tissue Reactions and Distant Tumor Growth.
TLDR
Although hepatic MWA can incite periablational inflammation and increased distant tumor growth similar to RFA in an animal tumor model, higher-power, faster heating protocols may potentially mitigate such undesired effects. Expand
No-Touch Radiofrequency Ablation of VX2 Hepatic Tumors In Vivo in Rabbits: A Proof of Concept Study
TLDR
No-touch radiofrequency ablation led to lower rates of peritoneal seeding and showed a tendency toward better LTC than DTP-RFA. Expand
Radiofrequency ablation triggers the migration of hepatocellular carcinoma cells by suppressing miR-148a-5p
TLDR
The study found that IRFA can increase the in vitro migration, invasion, and epithelial–mesenchymal transition (EMT) of hepatocellular carcinoma (HCC) cells via induction of Snail, a master regulator of EMT events. Expand
Minimally Invasive Therapies for Hepatocellular Carcinoma: Mechanisms of Local Control and Systemic Immunologic Response
TLDR
The mechanisms of thermal-based ablative techniques, advantages and disadvantages of each technique, subsequent Immunologic response following ablation, and advances in care that utilize combination therapy to potentiate the immunologic response creating a robust and long-term immunity to HCC are outlined in this chapter. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 33 REFERENCES
Radiofrequency (RF) ablation of normal liver increases tumor growth of remote subcutaneous tumors in an animal tumor model
TLDR
Although RF ablation of normal liver is necessary to achieve an ablative margin, it can stimulate the growth of tumors remote from the ablation site and external to the treated organ in at least one animal model. Expand
Radiofrequency Ablation: Inflammatory Changes in the Periablative Zone Can Induce Global Organ Effects, including Liver Regeneration.
TLDR
Hematic RF ablation induces not only a local periablational inflammatory zone but also more global proliferative effects on the liver, which could account for some of the local and distant tumor recurrence observed after treatment. Expand
Radiofrequency Ablation of Small Hepatocellular Carcinoma in Cirrhotic Patients Awaiting Liver Transplantation: A Prospective Study
TLDR
RFA is a safe and effective treatment of small HCC in cirrhotics awaiting OLT, although tumor size and time from treatment predict a high risk of tumor persistence in the targeted nodule. Expand
The effect of partial hepatectomy on tumor growth in rats: In vivo and in vitro studies
TLDR
Results show that, depending on cell density in co‐cultures, a paracrine stimulating influence of hepatocytes on this type of colon carcinoma cells (CC 531) might be responsible for the increased tumor growth in vivo. Expand
Hepatocellular carcinoma: new options for image-guided ablation
TLDR
Radiofrequency (RF) ablation has been the most widely assessed alternative to PEI and established as the primary ablative modality for local treatment of HCC, leading to a better local control of the disease. Expand
The place of downstaging for hepatocellular carcinoma.
TLDR
The present review discusses which treatments and strategies are available for downstaging HCC on the basis of the published literature. Expand
Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks
TLDR
It is proposed that under the regenerative proliferative stress induced by liver resection, the genomic unstable hepatocytes generated during chronic inflammation escape senescence and apoptosis and reenter the cell cycle, triggering the enhanced tumorigenesis. Expand
Review of Radiofrequency Ablation for Renal Cell Carcinoma
TLDR
This review will discuss how minimally invasive, image-guided radiofrequency tumor ablation is being incorporated as a clinical tool for the treatment of renal cell carcinoma. Expand
Influencing factors for recurrence of hepatocellular carcinoma treated with radiofrequency ablation.
TLDR
Obtaining complete coagulation is an important factor to prevent local recurrence and the number of tumors predicted the distant recurrence in patients with HCC undergoing RFA. Expand
Long-Term Outcome of a Hepatocellular Carcinoma 7½ Years After Surgery and Repeated Radiofrequency Ablation: Case Report and Review of the Literature
An interesting case is presented of a 78-year-old patient with cirrhosis who was managed with combined treatment (surgery and radiofrequency (RF) ablation) for hepatocellular carcinoma (HCC) and hasExpand
...
1
2
3
4
...