Oncogenes in solid human tumours

@article{Pulciani1982OncogenesIS,
  title={Oncogenes in solid human tumours},
  author={Simonetta Pulciani and Eugenio Santos and Anne V. Lauver and Linda K. Long and Stuart A. Aaronson and Mariano Barbacid},
  journal={Nature},
  year={1982},
  volume={300},
  pages={539-542}
}
The identification and isolation of oncogenes capable of inducing malignant transformation on transfection into rodent cells from human tumour cells has opened the possibility of deciphering the processes involved in human carcinogenesis. With the exception of three human lymphomas1, the human transforming genes so far identified have been detected in established tumour cell lines1–8, raising the possibility that they might have been activated during in vitro manipulation of the cells. However… Expand
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References

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TLDR
The results indicate that a biologically active oncogene present in T24 human bladder carcinoma cells is molecularly cloned with lambda Charon 9A as the cloning vector. Expand
Isolation of a transforming sequence from a human bladder carcinoma cell line
TLDR
The oncogene appears to have undergone little, if any, amplification in several bladder carcinoma cell lines and is unrelated to transforming sequences detected in a variety of other types of human tumor cell lines derived from colonic and lung carcinoma and from neuroblastoma. Expand
Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts
TLDR
DNAs obtained from human, rabbit and mouse bladder carcinomas lines, a lung carcinoma line and rat neuroblastoma and mouse glioma lines, are able to induce transformation of NIH3T3 cells on transfection. Expand
Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.
TLDR
Results indicate that the transforming genes of these human tumor cell lines are the cellular homologs of two retroviral transforming genes. Expand
T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes
TLDR
A transforming gene isolated from T24 human bladder carcinoma cells is closely related to the BALB murine sarcoma virus (MSV) onc gene (v-bas), which implies that rather subtle genetic alterations have led to the activation of the normal human homologue of v-bas as a human transforming gene. Expand
Human-tumor-derived cell lines contain common and different transforming genes
TLDR
The results indicate that overlapping pathways leading to tumorigenesis may arise independently, and that at least three different transforming genes are present in these five lines. Expand
Activation of related transforming genes in mouse and human mammary carcinomas.
  • M. Lane, A. Sainten, G. Cooper
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1981
High molecular weight DNAs of five tumors induced by mouse mammary tumor virus (MMTV), two mouse mammary tumors induced by a chemical carcinogen, and one human mammary tumor cell line (MCF-7) wereExpand
Established cell line of urinary bladder carcinoma (T24) containing tumour‐specific antigen
TLDR
The permanent presence of tumour‐specific antigen (TSA) in this carcinoma cell line suggests that the TSA is a genetically determined characteristic of T24 cells. Expand
Three different human tumor cell lines contain different oncogenes
TLDR
Comparison of the common DNA fragments found in secondary foci derived from three different human tumor cell lines indicates that these three cell lines contain three different transforming genes. Expand
Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells
TLDR
It is found that T24, a cell line derived from a human bladder carcinoma, can induce the morphological transformation of NIH 3T3 cells, and the gene responsible for this transformation is human in origin, <5 kilobase pairs in size and homologous to a 1,100-base polyadenylated RNA species found in T24 and HeLa cells. Expand
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