Oncogenes in solid human tumours

@article{Pulciani1982OncogenesIS,
  title={Oncogenes in solid human tumours},
  author={Simonetta Pulciani and Eugenio Santos and Anne V. Lauver and Linda K. Long and Stuart A Aaronson and Mariano Barbacid},
  journal={Nature},
  year={1982},
  volume={300},
  pages={539-542}
}
The identification and isolation of oncogenes capable of inducing malignant transformation on transfection into rodent cells from human tumour cells has opened the possibility of deciphering the processes involved in human carcinogenesis. With the exception of three human lymphomas1, the human transforming genes so far identified have been detected in established tumour cell lines1–8, raising the possibility that they might have been activated during in vitro manipulation of the cells. However… 
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References

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TLDR
The results indicate that a biologically active oncogene present in T24 human bladder carcinoma cells is molecularly cloned with lambda Charon 9A as the cloning vector.
Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.
TLDR
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TLDR
A transforming gene isolated from T24 human bladder carcinoma cells is closely related to the BALB murine sarcoma virus (MSV) onc gene (v-bas), which implies that rather subtle genetic alterations have led to the activation of the normal human homologue of v-bas as a human transforming gene.
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TLDR
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TLDR
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